Modificările imunităţii postvaccinale la bovine sub influența poliparazitozelor şi tratamentului antiparazitar complex (brovitacoccid, avomec, tilozină 200) [Articol]

Abstract

The results show that polyparasitism (Strongyloides papillosus, Neoascaris vitulorum şi Eimeria bovis, E. smithi, E. zuerni, E. ellipsoidalis) decreases total lymphocyte levels by 10% (P> 0.05), B-12, 6% (P <0.01), T -18.7% (P <0.01), but increase the amount of null lymphocytes by 31.4% (P <0.001), and these changes form a lower level of antibodies by 72% (P <0.01) compared to the group of uninfected animals and vaccinated anticolibacillary. Vaccination of calves treated with Brovitacoccid, Avomec and Tilozin 200 it was revealed a decrease in total lymphocyte level by 12.5% (P <0.05), B - 16.9% (P <0.001), T - 21.2% (P <0.01), but increased the amount of null lymphocytes by 21.2% (P <0.01). The impact of this treatment resulted in antocilibacillar antibody-specific titer lower by 82% (P <0.01) compared to uninfcted and vaccinated animals. This is probably due to the long-lasting immunotoxic effect of iatrogenic factor, which profoundly disrupts biochemical and biophysical processes in immunocompetent cells, including B lymphocytes producing specific antibodies.